Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator

AUTOR(ES)

Silva, Anna C., Benelkebir, Hanae, Lopes, Rosangela S. C., Lopes, Claudio C., Ganesan, A.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2018-05

RESUMO

The total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel condensation of an ortho-hydroxybenzaldehyde with Meldrum's acid under neutral conditions in water and one-pot acid catalyzed cyclization to the coumarin.

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