Topical treatment with honey, propolis in gel and allantoin cream in rabbit wounds experimentally infected / Tratamento tópico com mel, própolis em gel e creme a base de alantoína em feridas experimentalmente infectadas de coelhos

AUTOR(ES)

Napoleão Martins Argôlo Neto

DATA DE PUBLICAÇÃO

2005

RESUMO

The healing and antimicrobial effects of the honey, propolis in gel and allantoin cream were evaluated during the treatment of the rabbits wounds. The lesions were infected experimentally with Staphilococcus aureus coagulase positive, Pseudomonas aeruginosa and Pasteurella multocida in the concentration of 108 colony forming units (CFU)/mL. Significant differences were not observed (p <0.05) among the treatments for the variables intensity of the edema and size of the erythematosus halo. The treatments with saline solution, honey and allantoin cream did not also present difference (p <0.05) for the variable time of cicatrization. These results do not contest the antiphlogistic activity of the honey, propolis and allantoin cream, but demonstrates equivalent contribution with the cleaning of the lesions for the reduction of the local inflammation. In a contrary way, the propolis gel resulted in larger worsening of the infection and retard of the cicatrization of the wounds, when compared to the other treatments. The sensibility in vitro of the samples of S. aureus coagulase positive, P. aeruginosa and P. multocida to honey and propolis, in the same concentration inoculated in the lesions of the rabbits, was also evaluated by the technique of formation of the inhibition halo in middle of culture. The results showed that all the bacterial samples were sensitive to honey and propolis. However, these results diverge of most of the works that use honey and propolis, describing them as possessing low effect antimicrobial against P. aeruginosa and P. multocida. All these results stimulate the pursuit of new researches about the use of honey and propolis in the cicatrization of infected wounds, elucidating the real spectrum of antibacterial action of these composed and their affinity with the cellular differentiation during the reepithelization process.

ASSUNTO(S)

clinica veterinaria rabbit honey própolis propolis coelho mel

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