The presence of proteins hMLH1 and hMSH6 of DNA mismatch repair system in actinic cheilitis and squamous cell carcinoma of the lip / "A presença das proteínas hMLH1 e hMSH6 do sistema de reparo do mau pareamento do DNA em queilites actínicas e carcinomas epidermóides de lábio"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Actinic cheilitis (AC) results from chronic and excessive exposure of the lips to the ultraviolet radiation in sunlight. AC is recognized as a potentially malignant condition and it is estimated that 10% to 20% will become lip squamous cell carcinoma (LSCC). It has been suggested that virtually every LSCC was initially AC. It is well known that solar radiation causes DNA damage and, in this context, the DNA repair systems play an extremely important role in restoring the injuries. The purpose of this study was to evaluate the participation of the mismatch repair (MMR) system in AC with all grades of dysplasia, as well as, LSCC related to AC. The protein expression and distribution of two of these genes, hMLH1 and hMSH6 were analyzed by means of immunohistochemistry. The results have shown an association between decreased expression of hMLH1 and hMSH6 proteins and the progression of the dysplasia in AC and, therefore, LSCC carcinogenesis. In addition, the hMSH6 protein does not seem to have a primary role in DNA repair of the normal lip epithelium.

ASSUNTO(S)

sistema de reparo de mau pareamento do dna photocarcinogenesis dna mismatch repair system fotocarcinogênese queilite actínica hmlh1 immunohistochemistry lip squamous cell carcinoma hmsh6 carcinoma epidermóide de lábio imunoistoquímica actinic cheilitis hmsh6 hmlh1

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