Hmlh1
Mostrando 1-12 de 44 artigos, teses e dissertações.
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1. Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis
Abstract: Background: The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data. Objective: To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics. Methods: We analyzed
An. Bras. Dermatol.. Publicado em: 2016-08
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2. Leucoplasias bucais: estudo comparativo entre o grau histológico de displasia, imunoexpressão de hMLH1 e p53 e análise quantitativa de AgNOR
hMLH1 is a protein of the mammalian mismatch repair system (MMR), which maintains genomic stability during repeated duplication. Investigations point to a role of hMLH1 in oral carcinogenesis, and its expression pattern may be related to epigenetic events and microsatellite instability in oral leukoplakias and squamous cell carcinomas. It seems that those al
Publicado em: 2010
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3. Expressão de marcadores imunoistoquímicos de origem tecidual e de carcinogênese nos adenocarcinomas tipo intestinal e pancreatobiliar da ampola de Vater / Immunohistochemistry expression of tissue origin and carcinogenesis markers in adenocarcinomas of intestinal and pancreaticobiliary types of Vaters ampolla
INTRODUÇÃO: Os adenocarcinomas da ampola de Vater (AAV) são classificados conforme a diferenciação histológica em tipos pancreatobliliar e intestinal, com comportamento biológico e prognóstico diferentes. O objetivo deste estudo foi determinar um painel imuno-histoquímico para a diferenciação do tipo histológico dos AAVs e analisar os fatores rel
Publicado em: 2009
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4. Study of immunohistochemical expressions of: hMLH1, hMSH2 and Cox-2 in colon polyps / Estudo imunohistoquímico das expressões: hMLH1, hMSH2 e Cox-2 em pólipos do cólon
Pólipos adenomatosos colorretais são conhecidos como lesões pré-malignas. Mutações germinativas nas enzimas de reparo (MMR) hMLH1, hMSH2 e hMSH6 são causas reconhecidas de câncer colorretal hereditário não polipóide, induzindo um fenótipo mutante caracterizado por instabilidade de microssatélite (MSI). A MSI também é detectada em cânceres col
Publicado em: 2007
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5. Prevalência e valor prognóstico de marcadores moleculares em tumores colorretais esporádicos
O câncer colorretal (CCR) é o terceiro tumor em freqüência e o segundo em mortalidade nos países desenvolvidos. No Brasil, está entre as seis neoplasias malignas mais encontradas e é a terceira em mortalidade. Dentre todos os casos de CCR, cerca de 85% são esporádicos. A avaliação de prognóstico se baseia atualmente apenas em parâmetros clínico
Publicado em: 2007
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6. The presence of proteins hMLH1 and hMSH6 of DNA mismatch repair system in actinic cheilitis and squamous cell carcinoma of the lip / "A presença das proteínas hMLH1 e hMSH6 do sistema de reparo do mau pareamento do DNA em queilites actínicas e carcinomas epidermóides de lábio"
Actinic cheilitis (AC) results from chronic and excessive exposure of the lips to the ultraviolet radiation in sunlight. AC is recognized as a potentially malignant condition and it is estimated that 10% to 20% will become lip squamous cell carcinoma (LSCC). It has been suggested that virtually every LSCC was initially AC. It is well known that solar radiati
Publicado em: 2006
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7. Tumores gástricos primários múltiplos e únicos: análise imunohistoquímica comparativa / Multiple and solitary primary gastric tumors: comparative immunohistochemistry analysis
Introduction: Multiple primary gastric adenocarcinomas (MPGA) have been reported from 3.5% to 10% of all patients with gastric cancer. Tumoral multiplicity is largely known as an indicator of genetic predisposition for the development of neoplasias. Moreover, the route of carcinogenesis has not been clearly clarified in these tumors (mutator pathway or suppr
Publicado em: 2006
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8. Câncer colo-retal hereditário não polipose - Diagnóstico e surgimento de famílias de alto risco
O câncer colo-retal hereditário não polipose é uma síndrome genética caracterizada por uma susceptilidade aumentada para certos tipos específicos de câncer, especialmente o câncer colo-retal. Ao nível molecular, a síndrome caracteriza-se pela herança autossômica dominante de mutações em genes envolvidos em um mecanismo de reparo do DNA dirigid
Clinics. Publicado em: 2005-06
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9. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced by the associated instability of DNA microsatellite sequences (MSI). Germ-line hMLH1 mutations are causally associated with inherited MSI colon cancer, and somatic mutations are causally associated wit
The National Academy of Sciences.
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10. Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1
The mismatch repair (MMR) gene hMLH1 is mutated in ∼50% of hereditary non-polyposis colon cancers and transcriptionally silenced in ∼25% of sporadic tumours of the right colon. Cells lacking hMLH1 display microsatellite instability and resistance to killing by methylating agents. In an attempt to study the phenotypic effects of hMLH1 downregulation in gr
Oxford University Press.
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11. The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2
In human cells, hMLH1, hMLH3, hPMS1 and hPMS2 are four recognised and distinctive homologues of MutL, an essential component of the bacterial DNA mismatch repair (MMR) system. The hMLH1 protein forms three different heterodimers with one of the other MutL homologues. As a first step towards functional analysis of these molecules, we determined the inter
Oxford University Press.
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12. Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples
We performed a genetic and epigenetic study of the hMLH1 and hMSH2 mismatch repair genes in resected primary tumors from 77 non-small cell lung cancer (NSCLC) patients. The molecular alterations examined included the loss of mRNA and protein expression as well as promoter methylation, and the allelic imbalance of the chromosomal regions that harbor the genes
American Society for Clinical Investigation.