The maintenance of adipose tisssue is necessary to the metabolic control of diabetes mellitus induced in rats. / A manutenção do tecido adiposo é fundamental para o controle metabólico do diabetes mellitus induzido em ratos.

AUTOR(ES)

Julie Takada

DATA DE PUBLICAÇÃO

2008

RESUMO

A strong relationship between obesity and insulin resistance denotes the participation of adipose tissue in the pathogenesis of metabolic abnormalities seen in Diabetes Mellitus (DM). However, not only the excess, but the lack of adipose tissue can also trigger serious metabolic complications. The present study aimed to verify the role of adipose tissue on metabolic abnormalities seen in a DM experimental model induced by streptozotocin during neonatal period in rats, characterized by reduced adipose mass and presence of insulin resistance during adulthood. Five experimental groups were performed: non-diabetic control (C); treated diabetic with: insulin (I); pioglitazone (P); or metformin (M) and; non-treated diabetic (D). We verified that only I and P groups recovered body weight and adipose mass, concomitant to an improvement of insulin responsiveness The normalization of adipose mass in groups I and P is related to increased gene expression of transcription factors directly related to adipogenesis as well as increase in glucose incorporation into lipids. Therefore the maintenance of adipose mass exerts a key role in the metabolic control presented by this experimental model.

ASSUNTO(S)

diabetes adipose tissue resistência à insulina metabolismo de glicose lipogenesis expressão gênica glucose metabolism lipogênese gene expression tecido adiposo diabetes insulin resistance

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