Repercussões do destreinamento físico sobre o metabolismo e a celularidade do tecido adiposo branco periepididimal de ratos. / Physical detraining repercussions on metabolism and cellularity of white adipose tissue periepididymal in rats.

AUTOR(ES)

Rogério Antonio Laurato Sertié

DATA DE PUBLICAÇÃO

2010

RESUMO

All adaptations acquired through physical training are reversible during inactivity. Significant reductions in maximal oxygen uptake (VO2Max) are observed within two-four weeks of detraining. Conversely, the consequences of detraining on adipose tissue are poorly known. The objective was to investigate the physical detraining effects on metabolism and cellularity of rat periepididymal adipose tissue. Methods and Results: Male Wistar rats, ageing 6 weeks, were divided in 3 groups: trained (T) for 12 weeks; detrained (D), (trained for 8 weeks and detrained for 4 weeks), and age-matched sedentary (S). Training consisted in treadmill running sessions (1h/day, 5d/week, 50 60% of the maximal capacity). The morphometric analysis of PE tissue disclosed significant differences between the groups. The adipocyte sectional area of group D was significantly bigger than T and S (3474 µm2 ± 68,8 µm2 vs 1945,7 µm2 ± 45,6 µm2 vs 2492,4 µm2 ± 49,08 µm2, respectively). Compared to T the cells of D animals showed 48% increased ability to perform: lipogenesis, either spontaneously or insulin stimulated and isoproterenol-stimulated lipolysis. Basal lipolysis did not change. A 15% reduction in apoptosis was observed in groups T and D in relation to S. Some gene expressions were changed in D vs S: adiponectin (3-fold up) and PPAR-gamma (2-fold up). PREF-1 gene was 3-fold higher in T vs S. These results strongly suggest that adipogenesis was stimulated in this group. Conclusions: Detraining causes significant increase in adipocyte size and lipogenic capacity. As PE fat cell apoptosis was reduced in D and T, these results suggest that adipose tissue changes following detraining can potentially be obesogenic.

ASSUNTO(S)

adipogenese adipogenesis adipose tissue cellular metabolism exercício físico lipogênese lipogenesis lipolise lipolisis metabolismo celular physical training ratos rats tecido adiposo

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