Synthesis of the C(7)-C(20) Fragment of Spirotoamides A, B and C

AUTOR(ES)

Rossini, Allan F. C.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

12/08/2019

RESUMO

This work describes the preparation of the C(7)-C(20) fragment of spirotoamides A to C in a very elegant fashion, achievement very high levels of stereocontrol. The synthesis has been accomplished by a sequence involving 14 steps (0.36% overall yield, average of 81% for each step) in high diastereo and enantioselectivity, employing, as determining steps, asymmetric Mukaiyama and boron-mediated 1,5-anti promoted aldol reactions between α-methyl-β-hydroxyketones and aldehydes.

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