Synthesis and evaluation of octocrylene-inspired compounds for UV-filter activity

AUTOR(ES)

Polonini, Hudson C., Lopes, Rosângela S., Beatriz, Adilson, Gomes, Roberto S., Silva, Adriano O., Lima, Ricardo V. de, Nunes, Gláucia. A., Brandão, Marcos Antônio F., Raposo, Nádia R. B., Lima, Dênis P. de

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2014-07

RESUMO

Octocrylene (2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate) is present in several sunscreens and is known to work synergistically with UV filters. We prepared eight octocrylene-related compounds to test their photoprotective activities by measuring diffuse transmittance. The compounds had varied photoprotection profiles, with Sun Protection Factors (SPF) ranging from 1 to 5 and UVA Protection Factors (UVAPF) ranging from 1 to 8. Compounds 4, 5, and 7 showed the best protection against UVB sunrays, while compounds 5, 6, and 7 presented the best results for protection from UVA, so compound 7 had the most balanced protection overall. Results for compounds 4, 8, and 9 are reported for the first time in the literature.

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