Synthesis and biological evaluation of biaryl analogs of antitubulin compounds

AUTOR(ES)

Tozatti, Camila Santos Suniga, Khodyuk, Rejane Gonçalves Diniz, Silva, Adriano Olimpio da, Santos, Edson dos Anjos dos, Amaral, Marcos Serrou do, Lima, Dênis Pires de, Hamel, Ernest

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2012

RESUMO

This paper reports the synthesis of methanones and esters bearing different substitution patterns as spacer groups between aromatic rings. This series of compounds can be considered phenstatin analogs. Two of the newly synthesized compounds, 5a and 5c, strongly inhibited tubulin polymerization and the binding of [³H] colchicine to tubulin, suggesting that, akin to phenstatin and combretastatin A-4, they can bind to tubulin at the colchicine site.

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