Study the function of genes regulating the hypoxia state in determining the intensity inflammatory response. / Estudo da correlação entre a expressão de genes reguladores do estado de hipóxia e a intensidade da resposta inflamatória aguda.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Hypoxia occurs when the demand for molecular oxygen necessary to generate ATP is insufficient. Genes activated by hypoxia comprise the Hif-1a gene (Hypoxia-Inducible Factor 1a), Vegf-a (Vascular Endothelial Growth Factor a), Arnt and Vhl (von Hippel-Lindau). In this study we used lines of mice genetically selected for high (AIRmax) or low (AIRmin) acute inflammatory response (AIR). We conducted biological tests to characterize the inflammatory reactions produced by Biogel and TPA, and the type PAH carcinogen. We tested the mRNA expression of genes of hypoxia and characterization of polymorphism of the coding region of Hif-1a gene on chromosome 12. We found that the mice AIRmax had greater intensity of the inflammatory reaction that AIRmin to biogel and TPA while the reverse was observed with the DMBA. The data sets of phenotypes, gene expression and polymorphism applying the region of chromosome 12 that contains, among others, the gene Hif-1a, as part of the regulation of AIR.

ASSUNTO(S)

mice inflammation fator induzível por hipóxia 1a (hif-1a) hipóxia inflamação regulator genes genes reguladores receptores aryl de hidrocarbonetos (ahr) aryl hydrocarbon receptor (ahr) camundongos hypoxia hypoxia-inducible factor 1a (hif-1a)

ACESSO AO ARTIGO

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