Studies in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum: interferon-g and interleukin-4 mRNA expression

AUTOR(ES)

Marques, Cláudia S, Rolão, Nuno, Centeno-Lima, Sónia, Lousada, Hélder, Maia, Carla, Campino, Lenea, Rosário, Virgílio E do, Silveira, Henrique

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2005-12

RESUMO

This work aimed to study the T helper type 1/2 (Th1/Th2) cytokine profile in a co-infection murine model of Plasmodium chabaudi chabaudi and Leishmania infantum. Expression of interferon-gamma (IFN-g) and interleukin-4 (IL-4) was analyzed, in spleen and liver of C57BL/6 mice, by reverse transcriptase-polymerase chain reaction. High levels of IFN-g expression did not prevent the progression of Leishmania in co-infected mice and Leishmania infection did not interfere with the Th1/Th2 switch necessary for Plasmodium control. The presence of IL-4 at day 28 in co-infected mice, essential for Plasmodium elimination, was probably a key factor on the exacerbation of the Leishmania infection.

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