Characterization of Leishmania (L.) infantum chagasi in visceral leishmaniasis associated with hiv co-infection in Northeastern Brazil

AUTOR(ES)

Lima, Elaine Cristina Bomfim de, Barbosa Júnior, Walter Lins, Brito, Maria Edileuza Felinto de, Melo, Fábio Lopes de, Brandão Filho, Sinval Pinto, Medeiros, Zulma Maria de

FONTE

Rev. Inst. Med. trop. S. Paulo

DATA DE PUBLICAÇÃO

24/08/2017

RESUMO

ABSTRACT Visceral leishmaniasis, associated with HIV/AIDS coinfection, is becoming a more aggressive disease, complicating an accurate prognosis. A 21-year-old HIV-positive female presenting with clinical features of visceral leishmaniasis was enrolled in this study. Bone marrow cytology, Novy-MacNeal-Nicolle culture and kDNA PCR of peripheral blood were all positive. Typing methods, multilocus enzyme electrophoresis and ITS1-RFLP PCR of peripheral blood confirmed infection by Leishmania (L.) infantum chagasi . PCR has proved to be safer and more affordable than other characterization methods; ITS1-RFLP PCR can diagnose and type Leishmania spp. in both endemic and non-endemic areas, favoring the prognosis and allowing the appropriate treatment of patients.

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