Stability of freeze-dried plasma prepared from patients on oral anticoagulants

AUTOR(ES)
RESUMO

The suitability of freeze-dried plasmas from patients on oral anticoagulants to serve as reference material in the calibration of thromboplastins used in the control of oral anticoagulant treatment was assessed in two centres. One pooled normal plasma and four pooled plasmas from patients at different levels of anticoagulation were collected into HEPES-citrate containing Trasylol. The plasmas, in 1 ml volumes, were freeze dried in siliconized ampoules under the optimal conditions used for biological standards. Small aliquots of the same plasmas were stored at −70°C.

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