Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP)

AUTOR(ES)

Sant Ana Filho, Carlos R., Tavares, Claudinéia R. O., Ferreira, André V., Prestes, Clelber V., Bendassolli, José A.

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2013

RESUMO

The aim of the study was to synthesize the urea (13CO(NH2)2), with 99% 13C atoms, and to perform a quality analysis for the diagnosis (breath test) of Helicobacter pylori. Furthermore, the process was submitted to economic analysis. The reaction was performed in a stainless steel reactor, lined with polytetrafluoroethylene, under low pressure and temperature. The synthesis method was shown to be appropriate (2.35 g; 81.9% yield), evidenced by physico-chemical and microbiological results, according to Brazilian legislation. The production and diagnosis costs were competitive compared with national and international market values, rendering this a valuable tool in clinical medicine.

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