Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli.

AUTOR(ES)

Rosche, W A

RESUMO

The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded-DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

Documentos Relacionados

• The single-stranded DNA-binding protein of Escherichia coli.
• The single-stranded DNA-binding protein of Deinococcus radiodurans
• The product of the lexC gene of Escherichia coli is single-stranded DNA-binding protein.
• recA protein-catalyzed strand assimilation: stimulation by Escherichia coli single-stranded DNA-binding protein.
• Modulation of enzymatic activities of Escherichia coli DnaB helicase by single-stranded DNA-binding proteins