Serological Investigation of Chlamydia trachomatis Heat Shock Protein 10
AUTOR(ES)
Betsou, Fotini
FONTE
American Society for Microbiology
RESUMO
The humoral immune response to Chlamydia trachomatis 10-kDa heat shock protein (Chsp10) in populations of Russian and French origin was studied by using a recombinant Chsp10 enzyme-linked immunosorbent assay. A physiological but not a serological correlation of Chsp10 exposure with Chsp60 exposure was observed in the Russian population. In the French population studied, there was a significant association between detection of anti-r-Chsp10 immunoglobulin G (IgG) antibodies and chronic genital tract infections. Chsp10 residues 50 to 67 were found to contain an immunodominant although not universal B epitope. Cross-reactions with Chlamydia pneumoniae or Escherichia coli GroES protein are limited but may occur. Our study suggests that detection of anti-Chsp10 IgG antibodies is associated with chronicity of C. trachomatis genital tract infection and does not parallel that of anti-Chsp60 IgG antibodies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=96876Documentos Relacionados
- Cross-Reactivity between Chlamydia trachomatis Heat Shock Protein 10 and Early Pregnancy Factor
- Heat shock response of murine Chlamydia trachomatis.
- Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60.
- Antigen capture ELISA for the heat shock protein (hsp60) of Chlamydia trachomatis.
- The 75-kilodalton protein of Chlamydia trachomatis: a member of the heat shock protein 70 family?
