Cross-Reactivity between Chlamydia trachomatis Heat Shock Protein 10 and Early Pregnancy Factor
AUTOR(ES)
Betsou, Fotini
FONTE
American Society for Microbiology
RESUMO
Chlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis. Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=154954Documentos Relacionados
- Molecular basis for serological cross-reactivity between enteroviruses.
- Antigenic Cross-Reactivity Between Mycobacterium bovis (BCG) and Leishmania donovani
- Serological Investigation of Chlamydia trachomatis Heat Shock Protein 10
- Serological cross-reactivity between a porcine Actinobacillus strain and Haemophilus pleuropneumoniae.
- Search for cross-reactivity between HLA B27 and Klebsiella pneumoniae.
