Selectivity in the extraction of 2- quinolone alkaloids with supercritical CO2

AUTOR(ES)

Santana, L. L. B., Cardoso, L. A., Druzian, J. I., Souza, V. F., Costa, T. A. C., Nóbrega, D. A., Hohlemwerger, S. V. A., Velozo, E. S.

FONTE

Brazilian Journal of Chemical Engineering

DATA DE PUBLICAÇÃO

2006-12

RESUMO

This work describes the conditions for selective extraction of the alkaloids in Andreadoxa flava (Kallunki). The experiments were performed in a pilot plant SFE 500, in the following conditions. Extractor pressures 206.8 x 10(5), 241.3 x 10(5), 275.8 x 10(5) and 310.3 x 10(5) Pascal and pressures of 137.9 x 10(5), 69.0 x 10(5) and 55.2 x 10(5) Pascal for separators 6, 7 and 8 respectively. The temperatures were 40 °C in the extractor and 20 ºC in the separators. The samples, extracted from A. flava leaves, were analysed by ¹H NMR and GC/FID as well as by comparison with standards. This procedure allowed the identification for the first time of the 2-quinolone alkaloid 8-methoxy-N-methyl-flindersine in A. flava leaves of the. In addition, zanthophylline, 5-methoxyalmene and 8-methoxyflindersine were identified as the main alkaloids in leaves. Under the best conditions for zanthophylline extraction it was possible to obtain a purity of 79.4% while with other phytochemical technique 55.5% was obtained.

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