Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages
AUTOR(ES)
Bastos, A.C.S.C., Santos, L.B., Tamashiro, W.M.S.C., Yamada, A.T., Oliveira, U.M., Yano, T.
FONTE
Brazilian Journal of Medical and Biological Research
DATA DE PUBLICAÇÃO
2001-07
RESUMO
Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 µg/ml and 50 µg/ml) no significant difference was observed in the phagocytosis of E. coli F1+. However, at high THP concentrations (500 µg/ml and 1250 µg/ml) we obtained a reduction of bacterial phagocytosis by mouse peritoneal macrophages.
Documentos Relacionados
- Effect of Tamm-Horsfall urinary glycoprotein on phagocytosis and killing of type I-fimbriated Escherichia coli.
- Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization
- Immunofluorescent localization of Tamm-Horsfall mucoprotein in human kidney
- Bladder pseudo-tumor: case report of vesical tamm-horsfall protein deposit
- Polarized Expression of Tamm-Horsfall Protein by Renal Tubular Epithelial Cells Activates Human Granulocytes
