Retalho pré-fabricado composto por pele e vasos gastromentais terminais: estudo experimental em coelhos / Prefabricated flap composed of skin and terminal gastromental vessels: experimental study in rabbits

AUTOR(ES)

Jason César Abrantes de Figueiredo

DATA DE PUBLICAÇÃO

2008

RESUMO

INTRODUCTION: The angiogenic induction property of the omentum makes it a promising pedicle to prefabricate flaps. OBJECTIVE: To establish the abdominal area to be prefabricated by the omental pedicle and to analyze the prefabricate potential according to the time delay between the pedicle introduction and the flap release. METHODS: 44 rabbits were divided into four groups (A, B, C and D). In group A, a piece of skin, subcutaneous tissue and abdominal cutaneous muscle has been fully released and sutured again in its place. In other groups, a 9 cm2 omental pedicle containing the gastromental vessels distally tied has been transposed and sutured to abdominal cutaneous muscle. A second procedure, an incision and release of the flap that contained skin, subcutaneous and cutaneous abdominal muscle pediculated only by the omentum, has been carried out. The only variation was the time delay between the two procedures: 7, 21and 56 days for groups B, C and D, respectively. The flaps have been inspected 15 days after the last procedure, and the viable areas have been estimated using the software Image Tool®. The pieces of viable area have been immunostained using anti-CD31 allowing the estimation of the microvascular density. RESULTS: The mean and maximum viable areas in group D were 45.29 cm2 and 99.37 cm2 respectively (average prefabricate potential = 5.03 and maximum prefabricate potential = 11.04). There was no significant difference between the viable areas in groups C and D. The mean microvascular densities of groups B, C and D were 24.54 vessels/mm2, 33.20 vessels/mm2 and 27.03 vessels/mm2 respectively. This was higher than the mean microvascular densities of the control areas, which were 14.63 vessels/mm2, 17.33 vessels/mm2 and 18.12 vessels/mm2. In group A, there were total necrosis in all flaps. CONCLUSION: The prefabricate potential of the omentum was found to be 5.03 times its area and the delay time for the second procedure was, at least, 21 days

ASSUNTO(S)

neovascularização fisiológica omento retalhos cirúrgicos surgical flaps omentum physiologic neovascularization

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