Regulation of IL-2 signaling by fatty acids in human lymphocytes. / Efeito dos ácidos graxos sobre a via de sinalização da interleucina-2 em linfócitos humanos.
AUTOR(ES)
Renata Gorjão
DATA DE PUBLICAÇÃO
2008
RESUMO
The effect of fatty acids (FA) on interleukin -2 (IL-2) signaling pathway in human lymphocytes was investigated. Docosahexaenoic (DHA), eicosapentaenoic (EPA), palmitic (PA) and stearic (SA) acids decreased lymphocyte proliferation in concentrations above 50 mM. However, oleic (OA) and linoleic (LA) acids increase lymphocyte proliferation at 25 mM. PA, SA, DHA and EPA decreased JAK 1, JAK 3, STAT 5 and AKT phosphorylation induced by IL-2 but OA and LA did not cause any effect. OA and LA increased ERK1/2 phosphorylation whereas the other FA caused a marked decrease. PKC-Z phosphorylation was decreased by OA and LA only. In conclusion, the inhibitory effect of PA, SA, DHA and EPA on lymphocyte proliferation observed in our previous study was due to a decrease in protein phosphorylation activated by IL-2. Probably, OA and LA stimulated lymphocyte proliferation by increasing ERK 1/2 phosphorylation throught PKC-Z activation. The inhibition of JAK 1, JAK3, STAT 5, ERK1/2 and Akt phosphorylation caused by DHA is associated to a decrease in membrane lipid rafts contend.
ASSUNTO(S)
lipid raft linfócitos proliferação lipid raft lymphocytes sinalização intracelular interleukin 2 fatty acids Ácidos graxos proliferation intracellular signaling interleucina 2
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