PTK2 and PTPN11 expression in myelodysplastic syndromes

AUTOR(ES)

Lazarini, Mariana, Machado-Neto, Joao Agostinho, Archangelo, Leticia Frohlich, Mendes-Silva, Bruna Fernandes, Bigarella, Carolina Louzao, Traina, Fabiola, Saad, Sara Teresinha Olalla

FONTE

Clinics

DATA DE PUBLICAÇÃO

2013-10

RESUMO

OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. RESULTS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. CONCLUSIONS: Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors.

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