Production of the Hepatotoxic Chlorine-Containing Peptide by Penicillium islandicum Sopp1

AUTOR(ES)

Ishii, Kenji

RESUMO

Twenty-six strains of Penicillium islandicum Sopp were tested for production of a chlorine-containing peptide (Cl-peptide), which is a hepatotoxin. Highest levels of the mycotoxin were produced in a modification of Wickerham medium. The mycotoxin was isolated by adsorption on charcoal and, after washing the charcoal with acetone-water (1:1), was eluted into n-butanol. Further purification was accomplished by gel filtration. Maximum yields were 10 to 20 mg of toxin per liter of culture filtrate.

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