Production of Luteoskyrin, a Hepatotoxic Pigment, by Penicillium islandicum Sopp

AUTOR(ES)

Ueno, Yoshio

RESUMO

Various factors affecting the yields of luteoskyrin, a hepatotoxic mycotoxin, and related pigments in the liquid medium were studied. Maximal yields of luteoskyrin (0.13% by isolation) and of other pigments were attained in the late phase of the cultivation. The yield of the pigment was increased by supplying malt extract, malonic acid, glutamic acid, or asparagine. A useful material for preparation of 14C-labeled luteoskyrin was 2-14C-malonate.

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