Prevalência da resistência às drogas do Mycobacterium tuberculosis associada ao tratamento auto-administrado parcialmente intermitente comparada ao tratamento diário

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Background: Drug resistance relative to Mycobacterium tuberculosis is mainly due to the kind of treatment usually taken and is a problem to the therapy efficiency by itself. Objective: Compare mycobacterial resistance to drugs between two communities, one that takes partially intermittent therapy, and another that takes it daily. Methods: data from 5138 patients who had pulmonary tuberculosis with positive smear made by World Health Organization in Brazil were divided into two groups and analyzed. The first one was formed by the community who lives in Distrito Federal, where they use thrice weekly after one month of daily therapy. The second one was formed by the other regions of Brazil, where they use entirely daily therapy. The resistance was classified into primary or acquired as there was or not a history of past treatment. Multidrug resistance was only defined if at least both isoniazid and rifampin were involved. Results: Primary resistance prevalence as a whole was 9.2% in Distrito Federal, and 9.3% in other regions of Brazil (p = 0.94 ) while single resistance (any drug) and multi drug resistance were 6.6% and 6.9% (p = 0.89), 1.0% and 1.2% (p = 0.85), respectively. In relation to acquired resistance prevalence, it was 15.8% in Distrito Federal, and 26.8% in other regions of Brazil (p = 0.39), while single acquired resistance (any drug) and multidrug resistance were 5.3% and 13.7% (p = 0.33), 0.0% and 10.2% (p = 0.16), respectively. Conclusion: There wasnt any significant difference in resistance rates between people who has taken partially intermittent and daily therapy.

ASSUNTO(S)

pneumologia therapy terapia. tuberculosis resistência a medicamentos drug resistance tuberculose

ACESSO AO ARTIGO

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