Polimorfismos dos genes apolipoproteínas E e A5 e relação com parâmetros bioquímicos e hemostáticos em dislipidêmicos
AUTOR(ES)
Claudia Natalia Ferreira
FONTE
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia
DATA DE PUBLICAÇÃO
17/06/2010
RESUMO
Atherosclerosis is a complex process due to multiple genetic and environmental interactions that modify not only lipid metabolism but also the coagulation system and inflammatory response. Dyslipidemia is the most important risk factor for atherosclerosis, predisposing to cardiovascular disease. The aim of this study was to describe the allelic and genotypic distribution of the APOE and APOA5 -1131T>C polymorphisms and their relationship with lipid-lipoprotein plasma levels and hemostatic parameters in both dyslipidemic patients and normolipidemic subjects. The study included 216 individuals, distributed into 2 sub-groups, including 109 dyslipidemic subjects (41 women and 68 men, with a mean age of 48.4 ± 6.8 years) and 107 normolipidemic healthy volunteers (63 women and 44 men; mean age: 46.7 ± 6.6 years). Lipid levels were classified according to the Brazilian Society of Cardiology 2001. The frequencies of alleles and genotypes for the APOE polymorphism were homogenous between groups. As it was analysed the effect of APOE polymorphism on lipid levels in dyslipidemic and normolipemic groups, no significant differences were observed among E2, E3 and E4 and plasma lipid-lipoprotein levels in the dyslipidemic group. However, in the normolipidemic group, total cholesterol, LDLc and non-HDLc plasma levels were significantly lower in E2 patients compared to 3 and 4 (E2
ASSUNTO(S)
polimorfismo (genética) teses. hemostase teses. lipídios teses. lipoproteinas teses. sistema cardiovascular doenças teses. farmácia teses.
ACESSO AO ARTIGO
http://hdl.handle.net/1843/NCFA-8DAU5VDocumentos Relacionados
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