PHYTOCHEMISTRY INVESTIGATION OF CASEARIA ARBOREA (RICH.) URB. (SALICACEAE) AND ANTIMICROBIAL ANALYSIS OF ITS DITERPENE

Leite-Ferreira, Maria D., Rocha-Souza, Maria S., Ramirez, Raphael R. de A., Chaves, Otemberg S., Teles, Yanna C. F., Pereira, Fillipe de O., Braz-Filho, Raimundo, Lima, Edeltrudes de O., Sarquis, Rosangela do Socorro F. R., Silva, Tânia Maria Sarmento da, Souza, Maria de Fátima Vanderlei de

PHYTOCHEMISTRY INVESTIGATION OF CASEARIA ARBOREA (RICH.) URB. (SALICACEAE) AND ANTIMICROBIAL ANALYSIS OF ITS DITERPENE

AUTOR(ES)

Leite-Ferreira, Maria D., Rocha-Souza, Maria S., Ramirez, Raphael R. de A., Chaves, Otemberg S., Teles, Yanna C. F., Pereira, Fillipe de O., Braz-Filho, Raimundo, Lima, Edeltrudes de O., Sarquis, Rosangela do Socorro F. R., Silva, Tânia Maria Sarmento da, Souza, Maria de Fátima Vanderlei de

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2018-06

RESUMO

A phytochemical investigation from aerial parts of Casearia arborea (Rich.) Urb. (Salicaceae) led to isolation and identification of: sitosterol, 4-en-stigmast-3-one, 13-hydroxy-trans-ent-cleroda-3,14-diene,3-hydroxy-2-oxo-trans-ent-cleroda-3,14-diene (kolavelone), a mixture of 13-hydroxy-trans-ent-cleroda-3,14-diene and an ester ethyl hexadecanoate, kaempferol-3-O-a-L-arabinofuranoside and 4',5,7-trihydroxy-3',5'-dimethoxyflavone (tricin). The compounds have been described for the first time in this species. Five trihydroxy-flavone-hexoside derivatives have been identified by LC-ESI-HR-MS. The antimicrobial activity of kolavelone was evaluated against strains of Staphylococcus, Bacillus, Pseudomonas, Shigella and Candida spores, and its minimum inhibitory concentration (MIC) was determined. The results showed the antimicrobial activity of kolavelone against several bacteria and Candida tropicalis indicating its potential use as antimicrobial agent.