Phloem Mobility of Xenobiotics: I. Mathematical Model Unifying the Weak Acid and Intermediate Permeability Theories
AUTOR(ES)
Kleier, Daniel A.
RESUMO
A passive diffusion model has been developed which simultaneously accounts for the dependence of phloem mobility on permeability and acid dissociation. The model is consistent with the observation that the addition of an acid moiety to an otherwise phloem immobile compound may enhance that compound's ability to move in the phloem. However, acid trapping in the basic phloem is not the only enhancement factor. Acid functionalization also lowers the effective permeability usually towards its optimum value. The unified theory predicts that for a given acid dissociation constant there is an optimum permeability and conversely for a given permeability there is an optimum dissociation constant.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1054574Documentos Relacionados
- Phloem Mobility of Xenobiotics. I. Mathematical Model Unifying the Weak Acid and Intermediate Permeability Theories
- Phloem Mobility of Xenobiotics: II. Bioassay Testing of the Unified Mathematical Model
- Mathematical simulation model of the velvetbean caterpillar. I. Description of the model.
- A mathematical model of O2 transport in the rat outer medulla. I. Model formulation and baseline results
- Reductive beta-scission of the hydroperoxides of fatty acids and xenobiotics: role of alcohol-inducible cytochrome P-450.