Pharmacological activity from extracts obtained of lumber residue / Atividade farmacologica de extratos obtidos a partir de residuos madereiros

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

The knowledge about the use of medicinal plants is, innumerable times, the only therapeutic resource for several communities; and to search new bioactive compounds from Brazilian biodiversity is one strategy with positive economic and social consequences. Additionally, part of the tropical forest is explored for lumber and wood based products, generating annually about 10 million tons of residues, in the industrial manufacture processes. Joining the search of active principies with the possibility to use of lumber industry reject, the present research had as main objective to evaluate the potential for pharmacologic application of dichloromethane gross extract (EDB) and ethanol gross extract (EBE), extracted from residues of four tropical species (Tabebuia sp, Bowdichia Nitida, Dipteryx odorata e Myroxy/on ba/samum). Initially all the extracts had been tested to anticancer activity, in cultured human tumor cells. The EBD of Tabebuia sp, at concentration of 2,5 ug/mL, presented cytocide activity to ovarium carcinoma, melanoma and leukemia. The EBE of B. nitida at 25 ug/mL concentration showed cytocide activity to prostate adenocarcinoma, leukemia and melanoma. The EBD of D. odorata, at concentration of 25 ug/ml, presented selective cytocide activity for leukemia and ovarium carcinoma. EBD of M. balsamum demonstrated cytocide action, at concentration of 25 ug/mL,to melanoma, leukimia, breast and breas tresistant carcinoma, prostate, colon and kidney adenocarcinoma. The EBD of Myroxylon balsamum was experimented in other models, resulting depressing activity on central nervous system (CNS), such as hypnosis; antinoceptive action and untiulcer action. The wide range of M. balsamum EDB could be attributed to its particular chemical composition. Those results stimulate the continuity of studies with lumber residues, in the search of new therapeutic drugs

ASSUNTO(S)

wood waste antiulcer drugs agentes antineoplasicos hipnotismo residuos vegetais antineoplastic agents hypnostim drogas antiulcerogenicas

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