Pharmacokinetic Interpretation of Cephradine Levels in Serum After Intravenous and Extravascular Administration in Humans

AUTOR(ES)

Rattie, Elisabeth S.

RESUMO

Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kinetics and that biological availability is complete from all dosage forms.

Documentos Relacionados

• Pharmacokinetic Interpretation of Blood Levels and Urinary Excretion Data for Cefazolin and Cephalothin After Intravenous and Intramuscular Administration in Humans
• Intraventricular levels of amikacin after intravenous administration.
• Safety, tolerance, and pharmacokinetic evaluation of cefepime after administration of single intravenous doses.
• Pharmacokinetic study of isoquercitrin in rat plasma after intravenous administration at three different doses
• Effect of dose on serum pharmacokinetics of intravenous ciprofloxacin with identification and characterization of extravascular compartments using noncompartmental and compartmental pharmacokinetic models.