Pesquisa de anticorpos anti-HLA classe I e II em pacientes submetidos ao transplante renal / Anti HLA antibodies in renal transplanted patients

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

This prospective study evaluates the seric levels and anti-HLA antibodies? specificities of kidney receptor from dead donor, besides to esteem its influence in the etiology and its severity in the rejection crises. From June 2004 to August 2006, 40 transplanted kidney receptors had been analyzed with negative crossed test before of transplant and followed, clinically, at least 90 days after transplant. Patients were grouped by positive and negative rejection of clinical symptoms, being the group A made up of 26 positive cases and group B 14 negative cases. The serum samples for researching anti-HLA antibodies, applying the immunoenzimatic tests (One Lambda Incorporation), had been gotten just before and up to 60 days after the transplant, so that it coincides with increasing creatinine serum levels in the patients with bad evolution of engraftment. The anti-HLA antibodies results before transplant were negative. While the average number of HLA incompatibility (mismatched) between receptor and donor, considering HLA-A, B and DR loci, was 4/6 in both groups. Being in the group A the most frequent had been 4/6 and 3/6 and in the group B only 4/6. Among 26 patients of group A, 3 (11.5%) had developed detected anti-HLA antibodies in days: 16, 28 and 46 after transplant. The developed antibodies had been specific to donor?s antigens, being only one case belongs to the crossed reaction group, which it had also the donor?s antigens. These patients had an acute rejection of the vascular type. The others of this group presented reversible crises of rejection using immunosuppressive therapy (cyclosporine, mycophenolate and tacrolimus) determined by the Institution protocols. Group B did not develop anti-HLA antibodies. Although this sample is small, the results suggest the importance of creating antibodies that battle with donor?s HLA antigen due to severity of rejection crisis and therefore, its loss

ASSUNTO(S)

transplant kidneys rejeição de enxertos tecidos antigenos hla kidneys eliza graft rejection enzyme-linked immunosorbent assay transplante de orgãos rins rins - transplante etc teste imunoenzimatico hla antigens

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