Perfil imunoistoquímico dos tumores neuroendócrinos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Neuroendocrine tumours are a group of neoplasias that share morfofuncional characteristics but have a great variety of location, histogenesis, clinical presentation and prognosis. This study tests the immunohistochemistry profile of immunostaining to determine histogenetic characteristics and correlations with biological behavior determining factors. Twenty retrospective neuroendocrine tumors cases were selected and submitted to immunohistochemistry reaction with specific antibodies against synaptophysin, chromogranin, Ki67, p53, c- kit, VEGF, E-cadherin, 34βE12, CD99, e S-100. The immunoreactivity was scaled into a two and four-levels scale, and its frequencies were compared to the other variables age, sex, location, classification according to WHO and classification in two prognostic levels. Chromogranin was the most frequent marker, with moderate to strong immunoexpression in 95% of the cases, and the least frequent markers were CD99 and 34βE12, in 5%. Ki67 reaction was stronger in malignant tumors. E-cadherin was more frequently observed in tumours outside digestive and respiratory sites. The neuroendocrine tumours of the digestive tract had, respectively, S100 low expression and synaptophysin high expression. All the other variables tested were not statistically significant. This results made a histogenetic correlation. There is apparently specificity with chromogranin, synaptophysin and ki-67, and there is not with 34βE12. Some of this proteins are more frequent in specifical sites, as S100 and E-cadherin. VEGF, CD99, p53 and c-kit are expressed in small and not correlated to the studied variables subgroups of tumours

ASSUNTO(S)

imunoistoquímica neoplasia ciencias da saude tumores neuroendócrinos

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