Partial nucleotide sequencing of six subtype 2c hepatitis C viruses detected in Italy.

AUTOR(ES)

Cammarota, G

RESUMO

The great majority of 121 hepatitis C virus (HCV) isolates obtained from 117 Italian patients with community-acquired infection could readily be typed by genotype-specific PCR. Subtype 1b was dominant (74 isolates); subtypes 2b, 2a, and 1a followed, with 19, 14, and 8 isolates, respectively. The six isolates that remained untyped by this method were classified as subtype 2c on the basis of sequence analysis of PCR amplicors obtained from the core and NS5 genes. These findings indicate that HCV subtype 2c has a relatively high prevalence in Italy. Sequencing the core region from positions 160 to 259 is sufficient to distinguish subtype 2c from other known HCV genotypes.

Documentos Relacionados

• Identification of hepatitis C virus subtype 2c by sequencing analysis in patients from Córdoba, Argentina
• Subtype 2c of hepatitis C virus is highly prevalent in Italy and is heterogeneous in the NS5A region.
• Prevalence of hepatitis C virus genotypes in Italy.
• Mistyping of two Slovenian hepatitis C virus subtype 2c isolates as subtype 2b by two 5' noncoding region genotyping methods.
• Prevalence and awareness of hepatitis B virus carrier status in Italy.