Oxytocin and arginine vasopressin systems in the domestication process
AUTOR(ES)
Fam, Bibiana S.O., Paré, Pamela, Felkl, Aline B., Vargas-Pinilla, Pedro, Paixão-Côrtes, Vanessa R., Viscardi, Lucas Henriques, Bortolini, Maria Cátira
FONTE
Genet. Mol. Biol.
DATA DE PUBLICAÇÃO
26/03/2018
RESUMO
Abstract Domestication is of unquestionable importance to the technological revolution that has given rise to modern human societies. In this study, we analyzed the DNA and protein sequences of six genes of the oxytocin and arginine vasopressin systems (OXT-OXTR; AVP-AVPR1a, AVPR1b and AVPR2) in 40 placental mammals. These systems play an important role in the control of physiology and behavior. According to our analyses, neutrality does not explain the pattern of molecular evolution found in some of these genes. We observed specific sites under positive selection in AVPR1b (ω = 1.429, p = 0.001) and AVPR2 (ω= 1.49, p = 0.001), suggesting that they could be involved in behavior and physiological changes, including those related to the domestication process. Furthermore, AVPR1a, which plays a role in social behavior, is under relaxed selective constraint in domesticated species. These results provide new insights into the nature of the domestication process and its impact on the OXT-AVP system.
Documentos Relacionados
- Conformational Studies of Oxytocin, Lysine Vasopressin, Arginine Vasopressin, and Arginine Vasotocin by Carbon-13 Nuclear Magnetic Resonance Spectroscopy
- Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
- Evidence for the Differential Secretion of Oxytocin and Vasopressin in Man*
- Oxytocin and vasopressin neurones: vive la différence!
- Structure and comparison of the oxytocin and vasopressin genes from rat.