Oxidação e nitração de proteínas mediadas por peroxinitrito e peroxidases. Mecanismos, inibição por tempol e implicações patofisiológicas / Oxidation and nitration of proteins by peroxynitrite and peroxidases. Mechanisms, tempol inhibition and patophysiological implications

AUTOR(ES)

Sandra Muntz Vaz

DATA DE PUBLICAÇÃO

2008

RESUMO

The oxidants derived from peroxynitrite and peroxidase enzymes, such as myeloperoxidase (MPO), and the lesions they promote in proteins are being extensively investigated because of their relevance in inflammatory processes. Here, the proteins RNase and lysozyme were employed as targets of oxidations/nitrations mediated by peroxynitrite and MPO/HTyr92/97 >Tyr62/63 by peroxynitrite and in all Tyr by MPO/H

ASSUNTO(S)

tempol oxidation tempol nitração oxidação nitration peroxynitrite peroxinitrito peroxidases peroxidases

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