Organotin(IV) complexes with 2-acetylpyridine benzoyl hydrazones: antimicrobial activity

AUTOR(ES)

Despaigne, Angel A. R., Vieira, Lorena F., Mendes, Isolda C., Costa, Fernanda B. da, Speziali, Nivaldo L., Beraldo, Heloisa

FONTE

Journal of the Brazilian Chemical Society

DATA DE PUBLICAÇÃO

2010

RESUMO

Reações de tricloreto de n-butilestanho, [Bu nSnCl3], e tricloreto de fenilestanho, [PhSnCl3], com 2-acetilpiridina benzoil hidrazona (H2AcPh), 2-acetilpiridina-para-cloro-benzoil hidrazona (H2AcpClPh) e 2-acetilpiridina-para-nitro benzoil hidrazona (H2AcpNO2Ph) produziram os complexos [Bu nSn(2AcPh)Cl2] (1), [Bu nSn(2AcpClPh)Cl2] (2), [Bu nSn(2AcpNO2Ph)Cl2] (3), [PhSn(2AcPh)Cl2] (4), [PhSn(2AcpClPh)Cl2] (5) e [PhSn(2AcpNO2Ph)Cl2] (6). H2AcpClPh revelou-se a hidrazona mais ativa contra Staphylococcus aureus e Candida albicans. Pela coordenação a atividade antibacteriana tanto do metal quanto das hidrazonas aumenta significativamente. Os complexos 2 e 5 revelaram-se os mais ativos como agentes antimicrobianos.

Documentos Relacionados

• SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW SERIES OF ORGANOTIN(IV) ESTERS WITH N,N-DIACETYLGLYCINE
• Synthesis, Hypoglycemic Effect, Antimicrobial and Molecular Docking Studies of Organotin(IV) Complexes Derived From N-Phthalimido β-Amino Acid Derivatives
• Organotin(IV) esters of 4-maleimido-benzoic acid: synthesis, characterization and in vitro anti-leishmanial effects
• Organotin(IV) Derivatives of 2-Acetylpyridine-N(4)-Phenylthiosemicarbazone, HAP4P, and 2-Hydroxyacetophenone-N(4)-Phenylthiosemicarbazone, H2DAP4P: Crystal and Molecular Structure of [SnMe2(DAP4P)] and [SnBu2(DAP4P)]
• Antiviral Activity of 2-Acetylpyridine Thiosemicarbazones Against Herpes Simplex Virus