Ophthalmic suspension of dexametasone and polymyxin B: formulation and preservative antimicrobial efficacy / Suspensão oftálmica de dexametasona e polimixina B: formulação e avaliação da eficácia antimicrobiana de conservantes

AUTOR(ES)

Nádia Araci Bou Chacra

DATA DE PUBLICAÇÃO

1994

RESUMO

Ophthalmic suspensions of dexametasone and polymyxin B were formulated varying the preservatives and combining two concentrations of polysorbate 20 and hydroxypropylmethylcellulose according to the factorial project 2n. The stability of the preparations were evaluated through physical parameters, with emphasis on the easing of the rehomogenization after a period of rest. 8 of the 16 formula were selected for an evaluation of the antimicrobial efectiveness of the preservative system through the challenge method, according to B.P. 88, against Pseudomonas aeruginosa, Pseudomonas cepacia and Sthaphylococcus aureus. The test was preceded by a validation of the technique according to statistical planning two way and split + splot. The products containing the association of chorhexidine and phenylethyl alcohol complied to the requirements of the adopted compendium, in opposition to the systems containing benzalkonium chloride and EDTA, besides clorhexidine and EDTA, not depending on the concentration of the surfactant and suspending agents.

ASSUNTO(S)

dexametasone ophthalmic preservative dexametasona polymyxin colírio conservantes polimixinas

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