O-iodoxybenzoic acid in water: optimized green alternative for multicomponent one-pot synthesis of 2-amino-3,5-dicarbonitrile-6-thiopyridines

AUTOR(ES)

Takale, Santosh, Patil, Jaidas, Padalkar, Vikas, Pisal, Rajaram, Chaskar, Atul

FONTE

Journal of the Brazilian Chemical Society

DATA DE PUBLICAÇÃO

2012-05

RESUMO

Uma reação multicomponente do tipo one-pot de aldeído aromático, melanonitrilo e tiofenol na presença de ácido iodoxibenzóico (IBX) em meio aquoso forneceu 2-amino-3,5-dicarbonitrilo-6-tiopiridina em bons a excelentes rendimentos. Eventualmente, um catalisador poderia ser facilmente recuperado e reutilizado sem perda de sua propriedade catalítica.

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