A One-Pot Domino Synthesis of 5-(Trifluoromethyl)-2-thiazolamine

AUTOR(ES)

Bao, Xue-fei, Qiao, Xue-jun, Hou, Xiao, Fang, Wu-hong, Liu, Xue-long, Chen, Guo-liang

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2016-12

RESUMO

5-(Trifluoromethyl)-2-thiazolamine is a key intermediate for manufacturing numerous pharmaceuticals and chemicals. Here, a low-cost, one-pot multicomponent domino synthetic route has been reported for the synthesis of 5-(trifluoromethyl)-2-thiazolamine, which was successfully prepared from 3-bromo-1,1,1-trifluoro-2-propanone, phosphorus pentasulfide and cyanamide in the presence of sodium carbonate with the yield of 56%.

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