Músculo esquelético e envelhecimento: vias de sinalização da insulina e IGF 1 nos diferentes tipos de fibras musculares, perfil morfológico e efeito do DHEA em ratos apresentando sarcopenia. / Skeletal muscle and insulin action: intracellular pathway in type 1 and type 2 muscle fibers, morphological pattern, and effect of DHEA in sarcopenic rats.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Reductions in skeletal muscle mass, increased insulin resistance, and decrements in several hormones serum levels, including DHEA, are features observed in aging. Twelve to fourteen months old rats present specific regulation in the insulin and the IGF-1 intracellular pathway in distinct skeletal muscle fiber composition and show reductions in size and proportion of muscle composed predominantly by fiber type 2. DHEA treatment had no effect in these intracellular pathways but induces reduction in the size of type 1 fiber in the EDL muscle.

ASSUNTO(S)

tipos de fibra músculo esquelético fiber types sarcopenia insulin aging envelhecimento sarcopenia desidroepiandrosterona (dhea) insulina dehydroepiandrosterone (dhea) skeletal muscle

ACESSO AO ARTIGO

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