Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature

AUTOR(ES)

Otero, Luize, Souza, Daiane Correa de, Tavares, Rita de Cássia, Gomes, Bernadete Evangelho, Padilha, Telma França, Bouzas, Luiz Fernando, Fernandez, Teresa de Souza, Abdelhay, Eliana

FONTE

Genet. Mol. Biol.

DATA DE PUBLICAÇÃO

02/10/2012

RESUMO

Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.

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