Molecular epidemiology of human immunodeficiency virus-1 in the state of Ceará, Northeast, Brazil

AUTOR(ES)

Gadelha, Sandra Rocha, Shindo, Nice, Cruz, José Napoleão Monte, Morgado, Mariza Gonçalves, Galvão-Castro, Bernardo

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2003-06

RESUMO

We analyzed, by env and gag heteroduplex mobility assay, 149 human immunodeficiency virus (HIV-1) positive samples collected in Ceará during the year 2000. The prevalence of subtype B was 81.2% and the prevalence of subtype F and B/F recombinants were both 2.7%. Eight (5.4%) and 12 (8%) out of 149 samples showed indeterminate results in the env and gag analysis respectively. By FokI restriction fragment length polymorphism, 34% of the subtype B samples were identified as the typical Brazilian subtype B.In the present study, we identified HIV-1 subtype F and B/F in Ceará for the first time. Our results contribute to the understanding of HIV in Brazil, and may prove useful for the development of vaccine candidates.

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