Aspects of gastrointestinal immunology and nutrition in human immunodeficiency virus-1 infection in Brazil
AUTOR(ES)
Castello-Branco, Luiz RR, Ortigão-de-Sampaio, Maria Beatriz
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2000
RESUMO
Mucosal surfaces have a fundamental participation in many aspects of the human immunodeficiency virus (HIV) infection pathogenesis. In Brazilian HIV-1 infected subjects, loss of weight and appetite are among the most debilitating symptoms. In this review we describe a defined mucosal immunogen that has profound but transient effects on HIV viral load, and we suggest that gut associated lymphoid tissue under constant immunostimulation is likely to provide a major contribution to the total levels of HIV. We also show that hypermetabolism appears to play a role in the wasting process in Brazilian patients coinfected with HIV and tuberculosis.
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