Models of triple-stranded polynucleotides with optimised stereochemistry.

AUTOR(ES)

Arnott, S

RESUMO

Detailed models are presented for the triple-stranded polynucleotide helices of poly (U)-poly (A)-poly (U) (two forms), poly (U)-poly d (A) -poly (U), poly d(C)-poly d(I)-poly d(C), poly d(T)-polyd(A)-poly d(T) and poly (I)-poly (A)-poly (I). The models were genrated using a computerized, linked-atom procedure which preserves standard bond lengths, bond anglesand sugar ring conformations, constrains the helices to have the pitches and symmetries observed in X-ray diffraction experiments, and optimises the non-bonded interatomic contacts including hydrogen bonds. The possible biological sigificance of such complexes is discussed.

Documentos Relacionados

• Protein-free parallel triple-stranded DNA complex formation
• Intercalation of ethidium bromide into a triple-stranded oligonucleotide.
• Crystals of hemagglutinin-neuraminidase of parainfluenza virus contain triple-stranded helices.
• Formation of the triple-stranded polynucleotide helix, poly(A.A.U).
• Pyrimidine phosphorothioate oligonucleotides form triple-stranded helices and promote transcription inhibition.