MODELING OF THE CARDIAC ELECTRODYNAMICS AND OF THE EFFECTS OF SPATIAL AND TIME RESOLUTION ON OPTICAL MAPS / MODELAGEM DA ELETRODINÂMICA CARDÍACA E DOS EFEITOS DA RESOLUÇÃO ESPACIAL E TEMPORAL EM MAPAS ÓPTICOS

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

07/02/2011

RESUMO

Fluorescence studies using potentiometric dyes to optically measure the action potential of cardiac cells constitute an important tool to better understand the electrophysiology of the heart. However, in many experimental setups, the finite sensing area of optical detectors cannot be neglected. As a consequence, the detected fluorescence signal may effectively correspond to the sum of the electrical activity of a group of adjacent cells, and variations observed in the fluorescence signal may be strongly influenced by the spatial resolution of the optical instrumentation employed in the experiment. In addition, the optical action potential and the visualization of its propagation may be distorted by inadequate temporal resolution when recording optical maps. In this work, we present simulated and experimental studies demonstrating the effects of both temporal and spatial resolutions of the fluorescence detection system on electrophysiological parameter estimates obtained from optical action potential recordings. The analysis of the influence of the spatial and temporal resolutions of the optical fluorescence mapping detection system on the optical action potential morphology were performed by means of experimental optical mapping recordings, action potential simulations, and digital processing of the simulated and experimental signals.

ASSUNTO(S)

resolution processamento de sinais signal processing resolucao modelagem matematica mathematical modeling

ACESSO AO ARTIGO

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