Medroxyprogesterone acetate administered during pre-natal period causes hypospadia in male and virilization in female mice / "Acetato de medroxiprogesterona administrado em período pré-natal induz hipospádia em machos e virilização em fêmeas de camundongos"
AUTOR(ES)
Antonio Euclides Pereira de Souza Junior
DATA DE PUBLICAÇÃO
2005
RESUMO
In vitro fertilization (IVF) has been associated with an increase incidence of hypospadias. IVF protocols require the maternal use of progesterone which may be a factor in causing hypospadias. To test these hypotheses in an animal model, we describe the effects of maternal progesterone exposure on genital development in mice. Medroxyprogesterone acetate (MPA) was administered by subcutaneous injection during the pre-natal period to wild type mice and animals knockout to androgen receptors (Tfm mice). Progesterone caused hypospadias in male mice fetuses, a virilizing effect in the female mice genitalia and didn t have any effect in Tfm animals
ASSUNTO(S)
hipospÁdia/induzido quimicamente hypospadias/embryology hypospadias/etiology hipospÁdia/embriologia progesterone hipospÁdia/etiologia mice fertilizaÇÃo in vitro mice knockout virilismo hypospadias/chemically induced progesterona camundongos camundongos knockout virilism fertilization in vitro
