Marcadores de estresse oxidativo e de inflamação no sangue de cordão umbilical de recém-nascidos pré-termo de muito baixo peso e hemorragia peri e intraventricular / Oxidative stress and inlfammatory markers in umbilical blood cord and peri and intraventricular hemorrhage in very low birth weight infants

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

15/12/2011

RESUMO

This study evaluated the relationship between four laboratorial tests of oxidative stress and inflammatory markers and the development of intraventricular and periventricular hemorrhage (IVH) in very low birth weight infants (VLBW) - less than <1.500 g at birth. Cohort study accomplished in a neonatal intensive care at CAISM-UNICAMP, from May 2009 to October 2010. Infant with severe brain malformations, death before 6 hours of life and those whose umbilical blood samples weren´t obtained were excluded. Basal and under stimulation production of reactive intermediaries of oxygen (BROI and SROI), reduced glutathione (RG) and interleukin-6 (IL-6) were evaluated from umbilical blood. IVH was diagnosed by serial transfontanellar brain ultrasonography and classified according to Papile et al (1978). It was made at 6,12, 24, 72 hours of life and 7 and 28 days of life. Maternal factors, labor and delivery characteristics, and neonatal parameters were considered control independent variables and they were expressed in frequency. BROI, SROI, RG and Il-6 levels were expressed in medians and 25 and 75 percentiles. Chi-square or Fisher tests were used to determine the association of categorical variables and IVH. Mann-Whitney test were used to compare IVH and non-IVH groups and laboratorial markers medians. Univariate analysis was performed to identify differences between the IVH and non-IVH groups...Note: The complete abstract is available with the full electronic document.

ASSUNTO(S)

newbom estresse oxidativo interleucina-6 glutationa especies reativas de oxigenio recém-nascidos oxidative stress interleukin-6 glutathione reactive oxygen species

ACESSO AO ARTIGO

Documentos Relacionados