Limonin Derivatives: Synthesis Using Methodology in Solution and Heterogeneous Medium and Evaluation of the Antimicrobial Activity

AUTOR(ES)

Tavares, Luciana C., Fernandes, Tanize S., Ilha, Vinicius, Neto, Alexandre T., Santos, Eveline W. dos, Burrow, Robert A., Duarte, Fábio A., Flores, Erico M. M., Silva, Ubiratan F., Mostardeiro, Marco A., Morel, Ademir F.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2016-01

RESUMO

We herein described the preparation of a novel series of limonin derivatives (modification in A-ring), which was synthesized efficiently using methodology in solution as well as in heterogeneous medium (K-10). In addition, we obtained derivatives by inserting the 1,2,3-triazole nucleus via click reaction and also prepared derivatives from reactions with limonin-7-oxime. All compounds were submitted to investigation of the antimicrobial activity against a collection of microorganisms. The results of the antimicrobial activity, in general, demonstrated that a relevant number of synthetic derivatives presented higher activity than the natural product.

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