Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.

AUTOR(ES)

Sepetov, N F

RESUMO

Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.

Documentos Relacionados

• Tagged versus untagged libraries: methods for the generation and screening of combinatorial chemical libraries.
• Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents.
• Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem.
• Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly
• Identification of Novel Hexapeptides Bioactive against Phytopathogenic Fungi through Screening of a Synthetic Peptide Combinatorial Library