Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly
AUTOR(ES)
Huc, Ivan
FONTE
The National Academy of Sciences of the USA
RESUMO
Molecular and supramolecular diversity may be generated, respectively, by reversible, covalent or noncovalent self-assembly of basic components whose various potential combinations in number and nature represent a virtual combinatorial library. This concept is applied to the induction of inhibitors of carbonic anhydrase (CA) by reversible recombination of aldehyde and amine components. It is found that the presence of CA favors the formation of those condensation compounds that may be expected to present the strongest binding to the CA active site. The virtual combinatorial library approach may represent a powerful methodology for the discovery of substrates, inhibitors, receptors, catalysts, and carriers for a variety of processes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=20048Documentos Relacionados
- Supramolecular chemistry and self-assembly
- Control of biochemical reactions through supramolecular RING domain self-assembly
- Archimedean solids: Transition metal mediated rational self-assembly of supramolecular-truncated tetrahedra
- Electron microscopic study of supramolecular liquid crystalline polymers formed by molecular-recognition-directed self-assembly from complementary chiral components.
- Supramolecular self-assembly of d(TGG)4, synergistic effects of K+ and Mg2+.
